LEVENT KORKMAZ, MUSTAFA ALİ AKIN, TAMER GÜNEŞ, GHANİYA DAAR, OSMAN BAŞTUĞ, ALİ YIKILMAZ, SELİM KURTOĞLU
Journal of Clinical Research in Pediatric Endocrinology - 2014;6(3):177-179
Congenital hypothyroidism (CH) is the most common endocrine pathology in neonates. Inappropriate treatment of CH is complicated by irreversible brain damage or low IQ score. Hormone replacement therapy with L-thyroxine (L-T4) is sufficient for a very large proportion of patients. However, during treatment, the patient needs to be carefully monitored for presence of factors which might affect the absorption or bio-availability of the drug as well as its dose. Herein, we report a preterm newborn with CH who presented with gastrointestinal problems mimicking necrotizing enterocolitis. The clinical course was also complicated by cholestasis. The L-T4 replacement treatment was switched from oral route to parenteral. After resolution of the cholestasis, L-T4 treatment was continued successfully by the oral route.
