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PINEAL GLAND GERMINOMA AND PITUITARY INSUFFICIENCY PRESENTING WITH WEIGHT LOSS

EMİNE SENA SÖZEN, OĞUZHAN ZENGİN, ENES SEYDA ŞAHİNER

Ankara City Hospital Medical Journal - 2023;2(1):32-35

Department of Internal Medicine, Ankara City Hospital, Ankara, Turkey

 

Introduction Intracranial germinomas are rare cancers that primarily affect pediatric age group patients making them rarer still in adults. This report presents a case of a primary intracranial germinoma arising in the pineal region of a 24 year old male. The patient presented with a history of weight loss and progressive vision loss secondary to obstructive hydrocephalus. MRI demonstrated a large enhancing mass lesion in the region of the pineal gland with radiological features suggestive of a germinoma. Immunohistochemical stains confirmed the histological diagnosis, with positive staining for C-Kit, OCT4 and PLAP. In summary, this case report highlights that the diagnosis of pineal gland germinoma present in a young male is made by immunohistochemistry and detailed physical examination.